The effect of effective dose phytoestrogen of esteoperosis induced in femal rabbits | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 2, July 2014, Pages 121-134 PDF (0 K) | ||
| Abstract | ||
| This study was conducted to determine the impact of effective dose ED50 estrogenic plant (phytoestrogen)) extracted from the beans, white beans dry on the effectiveness female rabbits which induced Osteoporosis by bilateral removal of the ovaries .As for the experience of the second randomly divided 32 female rabbits (8 / group ) left the first group control group ( G1)) and removed the ovaries of the second group (G2) and injected into the third set to 0.2 mg / kg of plant estrogens without removing the ovaries have (G3) and treated Group IV with effective dose of (phytoestrogen) after the removal of the ovaries (G4). After some physiological parameters observed the following results : -In the group of animals removed ovaries and for a period of six months, observed a significant decrease (P <0.05) in the level of Estrogen (E) and the level of Glutathion (GSH) and phosphorus P in serum while observed a significant increase (P <0.05) at the level MDA and the level of calcium concentration and the level of effectiveness of Ca Alkaline Phosphate (ALP) in comparison with the rest of the groups.Group of animals removed ovaries and treated after six months (G4) observed a significant increase (P <0.05) in the level of estrogen E and GSH and p and a significant decrease (P <0.05) in MDA and Ca and ALP compared with the group removed the ovaries G2.Group of animals that were treated without removal of the ovaries G3 has been observed observed a significant increase (P <0.05) in the level of E and GSH and p, and a significant decrease (P <0.05) in the MDA and Ca and ALP, compared with a group of animals removed ovaries G2 and group G4.and For the study of histological observed deterioration in bone tissue with increase of the spaces in the body of bone tissue and affect the channels Volkmann group of female removed the ovaries . while when injection the effective dose of phytoestrogen observed lack of deterioration of bone tissue. | ||
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