Effect of Vitamin A on the Clinical Outcome of Acute Rotavirus Diarrhea in Preschool Children | ||
| Annals of the College of Medicine, Mosul | ||
| Article 7, Volume 45, Issue 2, December 2023 PDF (453.95 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/mmed.2023.143089.1231 | ||
| Authors | ||
| Dania Ali Faiq1; Rabab A Salman2; Munther N. Jasim2; Bassim I. Mohammad3; Ahmed M Sultan* 4; Sinaa Abdul Amir Kadhim1 | ||
| 1Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah, Iraq | ||
| 2Department of Pediatrics, Al-Hussein Specialized Children's Hospital, Al-Qadisiyah, Iraq | ||
| 3Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah | ||
| 4Department of Pharmacology and Therapeutics, College of Pharmacy, University of Al-Qadisiyah, Al-Qadisiyah , Iraq | ||
| Abstract | ||
| Background: Rotavirus infection is the most significant cause of severe dehydrating diarrhea, responsible for 5–10 million fatalities annually despite vaccinations. Acute rotavirus is the leading cause of vitamin A insufficiency by many mechanisms. Aims: To study the acute prognostic clinical effect of the addition of vitamin A on treating preschool-age patients with confirmed infection with acute rotavirus diarrhea. Materials and methods: A randomized, double-blind study of 55 children from 6 to 72 months aged in Al-Hussein hospital for children with positive acute rotavirus infection from October 2022 to May 2023 in Al-Diwaniya city in Iraq, was classified into two groups with a vitamin A dose of 100000 IU for those age less than 12 months and 200000 IU for those older given in the first day of involvement, while the other group received a placebo. Results: Vitamin A significantly decreased stool consistency and frequency to significant levels and reduced the diarrheal severity of acute rotavirus and the period of hospitalization from 7.18 days to 5 days only. Conclusion: Vitamin A intake in acute rotavirus infections significantly reduces the severity of diarrhea and hospitalization. | ||
| Keywords | ||
| gastroenteritis; rotavirus; vitamin A; children | ||
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