T. ALI, A., S. HAMEED, A., E. EBRAHIM, H. (2012). SYNTHESIS OF SOME NEW DRUG DELIVERY POLYMERS THROUGH IMINE GROUP AND STUDYING THEIR IN VITRO RELEASE.. Alustath, 4(3), 14-27. doi: 10.37652/juaps.2010.15570
ALI T. ALI; AYAD S. HAMEED; HALA E. EBRAHIM. "SYNTHESIS OF SOME NEW DRUG DELIVERY POLYMERS THROUGH IMINE GROUP AND STUDYING THEIR IN VITRO RELEASE.". Alustath, 4, 3, 2012, 14-27. doi: 10.37652/juaps.2010.15570
T. ALI, A., S. HAMEED, A., E. EBRAHIM, H. (2012). 'SYNTHESIS OF SOME NEW DRUG DELIVERY POLYMERS THROUGH IMINE GROUP AND STUDYING THEIR IN VITRO RELEASE.', Alustath, 4(3), pp. 14-27. doi: 10.37652/juaps.2010.15570
T. ALI, A., S. HAMEED, A., E. EBRAHIM, H. SYNTHESIS OF SOME NEW DRUG DELIVERY POLYMERS THROUGH IMINE GROUP AND STUDYING THEIR IN VITRO RELEASE.. Alustath, 2012; 4(3): 14-27. doi: 10.37652/juaps.2010.15570

SYNTHESIS OF SOME NEW DRUG DELIVERY POLYMERS THROUGH IMINE GROUP AND STUDYING THEIR IN VITRO RELEASE.

Journal of University of Anbar for Pure Science
Article 5, Volume 4, Issue 3, December 2010, Pages 14-27    PDF (780.1 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2010.15570
Authors
ALI T. ALI1; AYAD S. HAMEED* 2; HALA E. EBRAHIM3
1College of Science - University of Tikrit
2College of Education - University of Tikrit
3College of Pharmacy - University of Tikrit
Abstract
ABSTRACT:[A,B and C] Contains formyl group were synthesized through the condensation
polymerization of [Ortho, Meta, Para] – hydroxyl benzaldehyde with formalin in basic medium. The
prepared polymers were reacted with different drugs containing amino groups [ Aldomet , Isonizide ,
Sulfamethoxazole ,Folic acid ] through condensation reaction to gives twelfth new polymers. The
structures of these polymers were characterized using [ IR, U.V] spectral data, the result obtained are
compared with their assigned structures.The prepared polymer conjugated supported drugs were
studied for controlled drug release in- vitro at following pH [7.3, 9.4, 1.2] and at constant temperature
[25C ◌ْ ] . The obtained result indicate that the polymer structure and pH media have a significant
effects on controlled drug release .
Keywords
phenol; formaldehyde resins; Drug Delivery System; polymeric prodrugs
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