Side Effects of Ribavirin Drug on Mice Embryos and their Skeleton | ||
| Jornal of Biotechnology Research Center | ||
| Article 1, Volume 10, Issue 1, June 2016, Pages 5-10 | ||
| Authors | ||
| Safa S. Salman; Adel F. Shihab; Saad M. Nada | ||
| Abstract | ||
| This study focused on the cytogenetic effect of Ribavirin (RBV) drug on teratogenic lab animals (Mice). Several cytogenetic analyses (skeleton abnormal of embryos in mice). Studied the genetic effect of drug (RBV) on mice. That mice were divided into five experiment groups as the following: Negative control group: Animal orally treated with PBS buffer, positive control group was treated with (CP) and three groups treated with (RBV) with concentration 10, 20, 50 mg/kg, in other experiment studied teratogens of drug (RBV) result show significant differences (p<0.05) in body weight of mice embryo of study groups, negative control group recorded rate highly in embryo body weigh was (1.55) gm. While recorded positive control group rate less in weight of orally treated groups with (RBV) with concentration 10, 20, 50 mg/kg were 0.89, 0.71, 0.61 gm. Respectively the result show influences to (RBV) in embryo number at high concentration (50) mg/kg, while show died embryos in positive control group. Also the result shows abnormality in skeleton of embryos at concentration of drug 50 mg/kg. | ||
| Keywords | ||
| Ribavirin Drug; white mice | ||
|
Statistics Article View: 188 PDF Download: 48 |
||