Synthesis and Characterization of Some NewThiazine ,Azetidineand Thiazolidine Compounds Containing 1,3,4-Thiadiazole Moiety And Their Antibacterial Study. | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 27, Issue 3, December 2014, Pages 350-364 | ||
| Authors | ||
| Ali H. Samir; Khalid F. Ali; Ruwaidah S. Saeed | ||
| Abstract | ||
| 2-amino-5-mercapto-1,3,4-thiadiazole [I] were prepared by the cyclization of thiosemecarbazide with carbon disulphide and anhydrous sodium carbonate in ethanol as a solvent. The reaction of compound [I] with alkyl halides yielded 2- amino-5-thioalkyl-1,3,4- thiadiazole [II] and [III] . Compound [II] and [III] werereacted withdifferent aromatic aldehydes to yieled 2-[(substituted benzyliden ) amino] -5- thioalkyl-1,3,4- thiadiazole [IV]a-c , [V]a-d and [VI]a-d . Schiff ,s bases [IV]a-c , [V]a-d and [VI]a-d were found to react with 2-mercapto benzoic acid in the triethyl amine to give 3-[ 5-( alkylthio) -1,3,4- thiadiazol-2-yl] -2,3- dihydro- 2- (aryl) benzo [e] [1,3] thiazine -4-one [VII]a-c and [VIII]a . The Schiff ,s bases reacted with chloro acetyl chloride in the triethyl amine to give 3-chloro-1-(5-alkylthio)-1,3,4-thiadiazole-2-yl)-4-(aryl)azetidine-2-one[IX]a,b , [X]c and [XI]c,d .Also Schiff ,s bases reacted with 2-mercapto acetic acid in dry benzene to give 3-(5-mercapto-1,3,4-thiadiazole-2-yl)-2-(aryl)thiazolidine-4-one[XII]a,c ,[XIII]d and [XIV]]c,d. The structures of the newly synthesizedcompounds were confirmed by physical properties and spectral (UV-Vis , FT-IR and1H-NMR) analysis. | ||
| Keywords | ||
| thiadiazole; Thiazine; One; Azetidine; thiazolidine | ||
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