Synthesis, Characterizationand Antibacterial Activity of Some New Five-Seven Membered Rings AttachedtoSulfonamideCompounds | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 27, Issue 2, August 2014, Pages 170-177 | ||
| Authors | ||
| ; Shimaa A.Saoud; Ahmed A.Ahmed; Eman F.Mustafa | ||
| Abstract | ||
| This work includes the synthesis of some new five- seven heterocyclic rings derived from benzenesulfonylhydrazide as starting material. Its condensation with 4-methoxy and 4-nitro benzaldehyde givesthe Schiff bases (1a,b). Schiff bases were reacted with cyclic anhydrides given Oxazepine, Thiazepine derivatives(2,3,4 a,b)(seven membered ring) and with 2-mercapto benzoic acid gives thiazine derivatives (6a,b)(six membered ring) finally with thioglycolic acid give thiazolidine ring(five membered ring) scheme(3). The synthesized compounds have been characterized by melting points,FT-IR,1H-NMR spectroscopy ,13C-NMRand Elemental analysis. some ofsynthesized compounds were tested for their antibacterial activity against staphylococcus aureus,pseudomonous aureousandEscherichia coli.The results showed good efficacy against these types of bacteria. | ||
| Keywords | ||
| sulfonamide; oxazepine; Thiazepine; Thiazine; thiazolidine; Schiff bases; antibacterial activity | ||
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