Synthesis and antimicrobial evaluation of new 1,3,4 – Thiadiazole Derivatives | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 27, Issue 1, April 2014, Pages 297-305 | ||
| Authors | ||
| Iman F.Mustafa; Eman M. Hussain | ||
| Abstract | ||
| The amino thiadiazole [I] on treatment with aromatic aldehydes yielded Schiff bases [IIa-c] , which cyclized to thiazolidinone [IIIa-c] derivatives by reaction with thioglycolic acid .Reaction of carbon disulfide and methyl iodide with [I] gavedithiomethyl[IV] which on treatment with o-phenylenediamine gave the condensed N-Imidazolythiadiazolylamine [V] , However , reaction of [I] with phenylisocyanate and phenylisothiocyanate afforded the carbamideandcarbothiamide derivatives[VI.VII]a-c. The structure of these compounds was characterized from their melting point , FTIR spectroscopy and elementalanalysis | ||
| Keywords | ||
| antimicrobial; thiadiazole; Thiazolidinone; imidazoly; thiadiazolylamine | ||
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