Serum levels of several types of cytokines associated with Chronic Cholecystitis in Basrah /south of Iraq. | ||
| basrah journal of science | ||
| Article 1, Volume 32, Issue 2, December 2014, Pages 248-280 PDF (0 K) | ||
| Authors | ||
| Muthena M. Muthena; Awatif H. Issa | ||
| Abstract | ||
| Acute cholecystits is an acute inflammation of the gallbladder. A Total of 52 Cholecystectomy patients from a Al- Sadar Teaching hospital and 52 healthy volunteers were enrolled . Blood specimen collected by sterile container from both . The serum levels of pro-inflammatory cytokines (IL-1, TNF-α & IL-6) were significantly increased in gallstone patients sera comparing to healthy controls at (p<0.05) .While anti-inflammatory cytokine IL-4 concentrations in gallstone patients sera showed significant reduced comparing to healthy controls at (p<0.05). And regulator cytokine IL-17 concentrations in gallstone patients sera showed not significant reduced comparing to healthy controls at (p<0.05), . Finally IgG concentrations in gallstone patients sera showed significant elevation comparing to healthy controls at (p<0.05).The elevation of pro-inflammatory cytokines including (IL-1 , IL-6 & TNF-α) indicated the presence of inflammatory response associated with gallstone. The reduction of anti-inflammatory cytokine (IL-4) and regulator cytokine (IL-17) indicated the presence of immune predisposition in patients for gallstone. | ||
| Keywords | ||
| Cholecystitis; Gallstone; Cholecystectomy; cytokines | ||
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