Platelet indices and their relations to platelet count in hypo-productive and hyper-destructive Thrombocytopenia | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 7, Issue 2, December 2014, Pages 1952-1958 PDF (0 K) | ||
| Authors | ||
| Khaleed Jumaa Khaleel; Abeer Anwer Ahmed | ||
| Abstract | ||
| ackground: Thrombocytopenia is low platelets count which is either due to defective platelet production (hypo-productive thrombocytopenia) or due to increased platelet breakdown (hyper-destructive thrombocytopenia). Measurement of platelet counts alone do not explain the underlying patho-mechanism of thrombocytopenia.. Recent advances in automated blood cell analyzers facilitate the measurement of several blood cell parameters automatically such as, platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) and these parameters could provide some important clinical information. Aim of the study: to investigate whether platelet indices( MPV,PDW,PCT) could serve as diagnostic tools in the differential diagnosis of thrombocytopenia and, if there is any correlation between platelet count and platelets indices . Subjects and Methods: A total of 77 Iraqi patients (28 males and 49 females) with thrombocytopenia were subjected to the following tests: 1. Complete blood count using Mindway haematologic autoanalyser. 2. Peripheral blood film . 3. Bone marrow aspirate with bone marrow trephine biopsy when indicated. A group of 50 healthy person (age & sex matched) were included as a control Results: hyper-destructive thrombocytopenia (immune thrombocytopenia) representing 12.9% of total patients, while hypo-productive thrombocytopenia due to various causes representing 87.1% of total patients. The MPV, PDW are significantly higher in immune thrombocytopenia group as compared with thrombocytopenia of hypo-productive patho-mechanism and there were no correlations between platelets count and both MPV and PDW in hyper-destructive and hypo-productive thrombocytopenia but there was a direct correlation between platelet count and PCT . Conclusion: Platelet indices provide plenty of clinical information about the causes and patho-mechanism of thrombocytopenia and could be helpful tests to distinguish hyper-destructive thrombocytopenia from hypo-productive thrombocytopenia easily, so more interest for the use of these indices in differential diagnosis of thrombocytopenia is required. | ||
| Keywords | ||
| platelet indices; platelet count; thrombocytopenia | ||
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