Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 56, Issue 4, December 2014, Pages 401-404 | ||
| Authors | ||
| Laith Abul-Ellah Kamel; Ghuroob D. Dhamad; Madha M. Sheet Saleh | ||
| Abstract | ||
| Background: Diabetic nephropathy (DN) represents the most common cause of end stage renal disease (ESRD) worldwide. Diabetic nephropathy occurs as a result of an interaction between hemodynamic and metabolic factors, however recent evidence shows an increase growing support for the notion that inflammation plays a key role in the pathogenesis of diabetic nephropathy. Objectives: To speculate the role of IL-18 and TNF-α proinflammatory cytokines in the initiation and development of diabetic nephropathy in T1DM and T2DM. Materials and methods: Eighty seven T1DM and T2DM patients with or without DN were enrolled. IL-18 and TNF-α cytokines were measured by solid phase immunosorbent assays. Materials and methods: Eighty seven T1DM and T2DM patients with or without DN were enrolled. IL-18 and TNF-α cytokines were measured by solid phase immunosorbent assays. Results: IL-18 had increased significantly in patients with DN compared to those without DN in T1DM and T2DM patients whereas TNF-α had exhibited a significant elevation among patients with DN compared to those without DN in T2DM but not T1DM. Conclusion: IL-18 is suggested to play a crucial role in the initiation, development, and progression of DN in T1DM and T2DM patients whereas TNF-α is playing a similar role but only in T1DM patients with DN. Key words: Diabetic nephropathy, interleukin-18, tumor necrotic factor-alpha. | ||
| Keywords | ||
| Diabetic Nephropathy; Interleukin; tumor necrotic factor; Alpha | ||
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