Precautionary Effect of Ginkgo biloba Against Mercury-Induced Acute Nephro-Hepatotoxicity in male Rats | ||
| Journal of University of Babylon | ||
| Article 1, Volume 22, Issue 9, December 2014, Pages 2405-2390 | ||
| Author | ||
| Shaima Obead Abd-Allh | ||
| Abstract | ||
| Mercury (II) is an important factor in nephro-hepatoxicity that can enter the body through marine diets and amalgams. The present study was designed to investigate the protective effect of the Ginkgo biloba leaves (GB) extract on acute mercury intoxication on the liver and kidney. Rats were divided into six groups. Group I as control;; group II and III rats were injected intraperitoneal with GB extract at dose of( 200,400) mg/kg.b.wt/day for twenty five days, group IV rats were given orally of mercuric chloride at dose (5 mg/kg b.wt) for five days ,group V were given mercuric chloride (5 mg/kg) for five days then rats received GB extract at dose (200 mg/kg/day) intraperitoneal for twenty five day ,and groupe VI rats were orally given mercuric chloride (5 mg/kg) for five days then rats received GB extract at dose (400 mg/kg/day) intraperitoneal for twenty five day, Twenty four hrs after last treatment all rats were euthanized ,all groups were treated daily . Mercury induced a significant increase in malondialdehyde (MDA) and a significant reduction in reduced glutathione (GSH) levels in tissue liver and kidney, significant changes in serum hepatic and renal function parameters (, alkaline phosphatase (ALP), total protein, , uric acid and creatinine.), Mercury founded marked degenerative and necrotic alterations in kidneys and liver tissue . Gingko biloba returned MDA and GSH to the normal values, improved the mercury-induced serum biochemical changes of kidney and liver functions as well as histopathological & histophotometry alteration. Our results suggest that acute mercury intoxication induced marked nephro-hepatic deleterious effects which were corrected by ginkgo biloba treatment. | ||
| Keywords | ||
| Ginkgo biloba; mercury; nephro; Hepatotoxicity; reduced glutathione; Malondialdehyde | ||
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