Study of the changes of vascular endothelial growth factor (VEGF),antioxidant capacity and oxidative stress in the sera of Iraqi patients with ischemic stroke | ||
| Journal of University of Babylon | ||
| Article 1, Volume 22, Issue 9, December 2014, Pages 2376-2371 | ||
| Authors | ||
| Moaed Emran Al-Gazally; Ali Hmod Al-Saadi; Ahmed Faisal Obed | ||
| Abstract | ||
| Background: Ischemic stroke is death of brain tissue due to interruption of blood flow to a region of the brain, caused by occlusion of a carotid or vertebral artery or , less likely, a cerebral vein. It accounts for 85% of all stroke cases. Ischemic stroke is rapidly developing clinical signs of focal ("or global ) disturbance of cerebral function, with symptoms lasting 24 hours or longer, or leading to death. Aim of the study: To find out the relation between vascular endothelial growth factor , antioxidant capacity and oxidative stress in the patients with acute ischemic stroke cases. Patients and Methods: Our study was conducted on (60) patients with acute ischemic stroke and (30) apparently healthy subjects were taken as control group. The sera obtained from the blood of patients and healthy subjects were used to measure the concentrations of vascular endothelial growth factor (VEGF), total antioxidant capacity (TAC) and malondialdehyde (MDA). Serum VEGF concentration was determined by using enzyme- linked immunosorbent assay (ELISA) . Total antioxidant capacity and malondialdehyde (MDA) were determined by using colorimetric method. Results: In comparison with the control group, the patients with acute ischemic stroke show a significant increase in VEGF (P < 0.01) and MDA (P < 0.01) concentrations, and a significant decrease in TAC concentration (P < 0.01) . Also we found a significant elevation of VEGF (P < 0.05) in hypertensive patients with ischemic stroke compared to normotensive patients .On the other hand , there was a significant decrease (P < 0.05) of TAC concentration in smoker patients compared to non smoker ones against a significant increase (P < 0.05) of MDA concentration of smoker patients compared to non smoker patients. Also MDA level found to be increase significantly ( P < 0.05) in ischemic stroke patient who were also diabetic in compared to non diabetic patients . Significant positive correlation also observed between VEGF and MDA concentrations (r=0.374,P<0.05) in patient group . Conclusion: Our results suggest a functional interplay among oxidative stress, antioxidants, and VEGF in patients with ischemic stroke. | ||
| Keywords | ||
| Ischemic Stroke; Vascular endothelial growth factor; Total antioxidant capacity; Malodia dehyde; ischemic; endothelial | ||
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