The effect of exposure to permethrin during organization Stages on some reproductive Hormoe and antioxidants in female rats | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 2, July 2014, Pages 111-120 PDF (0 K) | ||
| Abstract | ||
| The present studay was conducted at Veterinary Medicine college / University of Karbala to investigate the effect of exposure to Permethrin during gestation stage of life on some hormones related with reproductive and antioxidants . In the experiment 40 rats, 28 female and 12 male rats were used gestation, then pregnant female albino rats were separated from the stud and divided into four main groups ( 7 for each group) . the first group served as control, in which the rats orally gaveged with distal water 0.5 ml/kg/BW of 0.001 ethanol, and other three treated groups orally administered 0.02, 25, 75 mg/kg/day) respectively daily the pregenant female dosed permethrin daily according to their groups from gestational day 7 of gestation till the day 21 and their offspring were reared and hold without more dosing untile day 60 of age on the other hand, The reproductive hormone were significantly (P< 0.05) altered in response to exposure to Permethrin by reduction of Testosterone and elevation of Progesterone of all treated groups, The level of Prolactin, LH,FSH were significantly decreased of all treated groups . the level s of antioxidants of Super oxide dismutase and Total anticapcity were significantly decreased in all treated groups. In conclusion , the present study suggest that the permethrin exposure during organization stages of life casues Disturbance the hormone levels in females and we recommended avoiding exposure during pregnancy and during childhood to permethrin. | ||
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