PHYSIOLOGICAL AND BIOCHEMICAL STUDY FOR SPECIMEN OF CHILDREN SUFFERING OF ENZYME G6PD DEFICIENCY AT RAMADY CITY.

IBRAHEEM, MUSTAFA S.; AL-RAWI, KhALID F.; RASHIED, RASHIED M .

doi:10.37652/juaps.2013.97180

	PHYSIOLOGICAL AND BIOCHEMICAL STUDY FOR SPECIMEN OF CHILDREN SUFFERING OF ENZYME G6PD DEFICIENCY AT RAMADY CITY.
Journal of University of Anbar for Pure Science
Article 19, Volume 7, Issue 3, December 2013, Pages 115-120 PDF (477.54 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2013.97180
Authors
MUSTAFA S. IBRAHEEM^* ¹; KhALID F. AL-RAWI²; RASHIED M . RASHIED³
¹Department of Chemistry ,College of Science , University of Anbar ,Ramdi.Iraq.
²Department of Chemistry ,College of Science , University of Anbar ,Ramadi.Iraq.
³Department of Biology ,College of Science , University of Anbar ,Ramadi.Iraq
Abstract
Some blood variable and reduced Glutathione (GSH) concentration had been studied besides lipid peroxides (Malondialdehyde (MDA)) and the concentration of trace ions of the element (Fe+2 , Cu+2 , Zn+2) in the blood serum of ill mace children. The study including sixty children suffering of acute hemolytic anemia of ages between (1-10)years ,more over another 30 healthy childs appearance of the some ages as a control group .The result indicated significant decrease at (P ≤ 0.05) of the activity of the enzyme G6PD in the children suffering illness due to the enzymatic deficiency in comparison with healthy children where the value of the enzyme activity recorded illustrated that the suffered children recorded (1.77 ± 0.71) U/g.Hb while the healthy children was (12.64 ± 2.40) U/g.Hb . The result also showed the children suffering G6PD lack recorded low significant result (P ≤ 0.05) at both the concentration of hemoglobin , site of packed red blood cells , reduced Glutathione and the concentration of Zn+2 relatively to healthy, where its concentration for the suffering children (5.82 ± 1.16) g/dl , (18.43 ± 3.81) % , (2.95 ± 0.99) µmol/l and (15.78 ± 4.23) µmol/l while for the healthy were (11.95 ± 0.67) g/dl , (37.76 ± 1.98) % , (7.80 ± 2.20) µmol/l , (20.60±3.06) µmol/l respectively. While it revealed significant elevation (P ≤ 0.05) at both white blood cells and the MDA concentration ,besides the concentration of Fe+2 and Cu+2 at the Infected children regarding the healthy children. Where by its concentration at Infected children (8.46 ± 2.03)103 cell/mm3 , (20.83 ± 7.75) µmol/l , (81.75 ± 48.58) µmol/l and (44.29 ± 10.88) µmol/l. while for healthy were (16.14 ± 5.57)103 cell/mm3 , (8.98 ± 2.47) µmol/l , (33.48 ± 5.23) µmol/l and (33.19 ± 6.76) µmol/l. Respectively.

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