EFFECT OF ALUMINUM SULFATE ON SOME OF LIVER AND THE KIDNEY FUNCTIONS IN WHITE RAT Rattus norvegicus | ||
| Journal of University of Anbar for Pure Science | ||
| Article 13, Volume 7, Issue 3, December 2013, Pages 74-79 PDF (478.17 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2013.97174 | ||
| Author | ||
| ASMAA JUMAA ALSAMMARAI* | ||
| Department of Biology ,College of Education ,Samarra of University ,Samarra,Iraq. | ||
| Abstract | ||
| The present study concerned the effect of Aluminum Sulfate on some of liver and the kidney enzymes in white rat '' Rattus norvegicus '' . had used twelve rats for adult male and divided to four groups the concentration of Aluminum sulfate in first group was 75 mg 100 ml of distilled water the second was 150 mg 100 ml of distilled water & third 300 mg 100 ml of distilled water that’s gave as 1 ml per day ; the first group is considered as control group , while the other three groups are experimental groups . The study have found there are significant differences in ALP, ALT and AST enzymes in addition to Creatinine and Urea with dosage increase concentration of Aluminum sulfate by compare with control group (P≤0.05) However , there are no significant differences in ALT enzyme when concentration of this dosage is increased among experimental groups ( 1,2,3 ) . Adding to that there are significant differences in AST enzyme when concentration of this dosage is increased in experimental groups 1 , 2 and 3 (P≤0.05) while there are no significant differences in ALP and Urea when the concentration of the dosage is increased in comparison with experimental group 1,2,3 (P≤0.05).Finally , they are significant differences in Creatinin when the concentration of the dosage is increased in the experimental groups in comparison with 1,2 and 3 (P≤0.05 .The study shows that Aluminium sulfate effect negatively on the level and the activity of liver ALP ,ALT , and AST enzymes , Also , It has negative effect in the activity and the level of both creatinine and urea of kidneys whatever the concentration of the dosage in the water it was . In addition to that , there are differences in the effect of Aluminium sulfate on the ALP ,ALT , AST enzymes and creatinin and urea concerning levels of their activities inside Ruttus | ||
| References | ||
10. Sabatine, M.; Morrow, D.; and Lemos, J. (2002). Multimarker approach to risk stratification in non-ST clevation acute coronary syndromes. Circulation Journal, 105:1760-1763.
11. NAVRÁTIL, T.; KOHLÍKOVÁ, E.; PETR, M.; PELCLOVÁ, D.; HEYROVSKÝ,M.; and PŘISTOUPILOVÁ, K. (2009) . Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units. Physiological Research Journal, 59: 431-442.
12. العبد الله، شتیوی. (2012) . علم وظائف الأعضاء.ص375-401 ط1 دار المسیرة للنشر والطباعة والتوزیع، عمان – الأردن 13. 13. AL-Maliki, S.J. (2000). A behavioral and some physiological effects of (apumgraveolens) seed in albino mice (Mus Musculus L). Journal Sci. Bas., 18:77-88.
14. AL-Fartose, K.K. (2004). Physiology studies of the effect of benzene in laboratory mice and human. Ph.D. thesis Education college, Basrah University.
14. سلمان، حسین عباس. (2010). بعض المتغیرات الفسلجیة والنسیجیة فی ذکور الجرذان المختبریة المعرضة لجرع مختلفة من المضاد الفطریKetoconazole. مجلة علوم ذی قار. 2(2):21-27. 15. الراوی، خاشع محمود وخلف الله، عبد العزیز محمد. (2000) . تصمیم وتحلیل التجارب .ص65-95، دار الکتب للنشر، جامعة الموصل، الموصل - العراق . 16. Kant, V.; Srivastava, A.; Raina, R.; Verma, P.; and Singh, P. (2010). Negligible Amelioration by Aluminum Sulphate on subacute Fluoride-Induced Enzymatic Alterations in GOATS. Fluoride Journal, 43(4)246–252
17. TـRKEZ, H.; GEYİKOĞLU, F.; and OLAK, S. The protective effect of boric acid on aluminum-induced hepatotoxicity and genotoxicity in rats. (2011). Turkey Journal Biol, 35: 293-301
18. Abdel-Maksoud, Hussein A.; Fararh, Khalid M.; Mohamed M.; Fat-Hallah, M.; and Said, G. (2005). Effects of chronic aluminum administration on brain and liver enzyme activities and essential elements concentration in rats: protective role of vitamin A and riboflavin. Agriculture Sciences Building, Pp. 1-22.
19. Ali, T.; Paiker, E.; and Crowther, J. (2006). The Relationship Between Anthropometry and Serum Concentrations of Alkaline Phosphatase Isoenzymes, Liver Enzymes, Albumin, and Bilirubin. Am Journal Clin Pathol, 126:437-442
20. Piton, A.; Poynard, T.; and Imbert-Bismut, F. (1998). Factors associated with serumalanine transaminase activity in healthy subjects: conseguences for the definition of normal Values for selection of blood donors and for Patints with chronic hepatitis. C. Hepatology, 27:1213-9
21. Alter, MJ.; Kruszon-Moran, and D.; Nainan, DV. (1999). The Prevalence of hepatits C virus infection in united states, 1998 through 1994. N Eng. Journal Med. 341:556-62
22. Nwokocha, C.R.; Nwangwa, E.K.; and Udekweleze, D.C. (2011). THE DETOXIFICATION OF LEAD POISONING BY Garcinia kola IN ALBINO WISTAR RATS. Continental. Journal Biomedical Sciences 5(1):32–36
23. Drugă. Ma.; Trif. A.; Drugă. M.; Ştef, D. and Clep. C. (2005). The Consequences of Chronic Aluminum Sulfate Intake on Some Biochemical Parameters in Rats. Scientifical Researches, Agroalimentary Processes and Technologies Journal, XI(2):413-416. | ||
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