Oolong tea is a potential prophylactic anti-cancer herbal modality against mice bearing mammary tumor | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 7, Issue 2, December 2014, Pages 127-132 | ||
| Authors | ||
| Huda G. Hameed; Marwan S.M. Al-Nimer; Nahi Y. Yaseen | ||
| Abstract | ||
| Background: It is prepared from crushing and fermentation of the rims of the leaves of Camellia sinensis. It contained a plenty quantity of polyphenols that differed from that in the green or black tea. Objectives: This study aimed to demonstrate the anticancer effect of oolong tea extract against in situ mammary tumor in mice ex vivo experimental model, and to compare its effect with the gallic acid as antioxidant substance. Materials and methods: Mice bearing mammary tumor are used as a source of mammary tumor cells. The animals are treated intraperitoneally with 0.2 ml of distilled water (Group I) or gallic acid (1% w/v) or oolong tea-extract prepared with microwave assisted method (10% w/v) twice weekly. The animals were sacrificed by cervical dislocation after two weeks and the tumor masses were excised and processed for determination of total protein, malondialdehyde and histopathological findings. Results: Oolong tea extract and gallic acid induced changes in the morphology and texture of tumor mass compared with distilled water treatment. Oolong tea non-significantly increased the tumor mass-protein and malondialdehyde levels compared with Group I and Group II. The histopathological findings in term of giant multi-nucleated cell, necrosis, hemorrhage, and fibroblast cells infiltration that observed in Group (I) treated animals are improved in Group (III) animals Conclusions: Oolong tea acts as anti-cancer substance in a mechanism differed from that proposed by the gallic acid as antioxidant. | ||
| Keywords | ||
| Oolong tea; Mammary tumors; histopathology | ||
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