Antihyperlipidemic Effect of L-Thyroxine Combined with Carvedilol in Induced Hyperlipidemia in Rabbits | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 11, Issue 4, December 2014, Pages 1047-1059 | ||
| Authors | ||
| Muayyad Sraibit Abbod; Faruk H. Al-Jawad; Adnan A. Anoze; Mufeda Ali Jawad | ||
| Abstract | ||
| Background:Hyperlipidemia is defined as an elevation of one or more of the plasma lipids, including cholesterol, cholesterol esters, triglycerides (TG) and phospholipids .An elevation of plasma lipids may be caused by primary or secondary factors. Objective:To evaluate the effect of L-thyroxine - Carvedilol combination on hyperlipidemia induced in rabbits. Material and method:Forty healthy, domestic rabbits of both sexes, weighing (800 – 1100 grams) were used in this study. They were divided into five groups each one contains eight rabbits. The first group (G1) was given a standard diet to be considered as a control group while all other groups fed with high cholesterol diet. The second group (G2) was given high cholesterol diet only, third group (G3) treated with atorvastatin , (G4) treated with L-thyroxine and (G5) received L-thyroxine combined with carvedilol. Then lipid profile, heart rate and body weight were measured for all groups to be compared. Results:Because atorvastatin is a known antihyperlipidemic drug, the results of using combination of L-thyroxin with carvedilol were compared to those produced by atorvastatin alone. The results showed insignificant (p˂0.05) difference in all biochemical parameters, heart rate and body weight of the hyperlipidemic group treated with the combination of L- thyroxin and carvedilol (G5) when compared with those treated with atorvastatin alone (G3). Conclusion:The use of the combination of L-thyroxine and carvedilol has antihyperlipidemic effect similar to that of atorvastatin which is well known antihyperlipidemic drug. | ||
| Keywords | ||
| Hyperlipidemia; Thyroxin; Carvedilol; lipid profile; Atorvastatin | ||
|
Statistics Article View: 208 PDF Download: 91 |
||