Evaluation of CTLA-4 Gene polymorphism SNP 49 G/ A Association with Diabetes Mellitus Type 1 in Egyptian Population | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 55, Issue 4, December 2014, Pages 1547-1552 | ||
| Authors | ||
| Ali Salim Al-shehmany; Ahmad A. El- Kafoury; Medhat A. Haroun; Amira M. Embaby | ||
| Abstract | ||
| The (CTLA-4) encodes of the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. The contribution of CTLA-4 gene variants to type 1 diabetes has been analyzed in several ethnic groups. In this study, the association of CTLA-4 +49 A/G polymorphism with type 1 diabetes was investigated in Egyptian patients. Sixty type 1 diabetic patients (25 males and 35 females) and 60 healthy individuals (33 males and 27 females) subjects formed the studied populations. CTLA-4 A/G polymorphism at position 49 in exon 1 was identified using allele specific methods. Patient numbers with A/G, A/A and G/G genotypes were 45 (75.0 %), 6 (10.0 %) and 9 (15.0%) while in healthy controls, these were 48 (80.0%), 2 (3.3%) and 10 (16.7%), respectively. In conclusion, the results of this study showed that CTLA-4 +49 A/G polymorphism were not associated with susceptibility to type 1 diabetes in Egyptian population. | ||
| Keywords | ||
| Type; CTLA; polymorphism; susceptibility | ||
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