Detection of Human Leukocyte Antigen and Celiac Disease Auto Antibodies in serum of Patients with Multiple Sclerosis | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 55, Issue 4, December 2014, Pages 1477-1483 | ||
| Authors | ||
| Rana S. Aboud; May K. Ismael; Haider J.Mohammed | ||
| Abstract | ||
| To determine the important pathogenic role of celiac disease in triggering several autoimmune disease, thirty patients with Multiple Sclerosis of ages (22-55) years have been investigated and compared with 25 healthy individuals. All the studied groups were carried out to measure anti-tissue transglutaminase antibodies IgA IgG by ELISA test, anti-reticulin antibodies IgA and IgG, and anti-endomysial antibodies IgA and IgG by IFAT. There was a significant elevation in the concentration of anti-tissue transglutaminase antibodies IgA and IgG compared to control groups (P≤0.05), there was 4(13.33%) positive results for anti-reticulin antibodies IgA and IgG , 3(10%) positive results for anti-endomysial antibodies IgA and IgG . There were 4 positive results (13.33%) for HLA-DQ8 by using HLA-DQ8 Real-Time PCR test. These results indicated that patients with celiac disease play an important role in pathogenesis of Multiple Sclerosis. | ||
| Keywords | ||
| Multiple sclerosis; celiac disease; auto antibodies | ||
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