Estimation the concentration of IL- 23, and IL-17A in the sera of patients with psoriasis in Baghdad city | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 13, Issue 2, December 2014, Pages 75-85 | ||
| Authors | ||
| Hind Jabber Hassoon; Nidhal Abdul-Muhaimen; Farhan Abood Risan | ||
| Abstract | ||
| Abstract: Psoriasis is a common, chronic, disfiguring, inflammatory, hyperproliferation, and abnormal differentiation of keratinocyte, in which both genetic and environmental influences have a critical role. The study was designed to detection the levels of IL-23 and IL-17A among psoriatic patients compared with healthy group, also studied the correlation between them and some parameter such as:-age of onset and severity of psoriatic patients. Fifty psoriatic patients were selected randomly from both sexes with ages from (10-70) years. Patients were diagnosed clinically by dermatologist. Sera samples of both groups were collected from all individuals for the estimation levels of IL-23 and IL-17A by ELISA technique. All mean values sera levels (IL-23 96.74 pg/mL and 6.56 pg/mL for IL-17A ) of patients were significantly higher than those of controls (18.74 and 3.01 pg/mL for IL-23and IL-17A respectively). There was a high significant in levels of patients sera of IL-23 and IL-17A, in compared with healthy control group according to these normal values. Furthermore, there was a significant correlation between the levels of IL-23, and age of disease onset among psoriatic patients. In contrast there was no significant association between the severity & interleukins (Il-23 and Il-17A). Emerging data in humans reveals a critical contribution of IL-23 and IL-17A in the pathogenesis of psoriasis. The IL-23 and IL-17A pathways were atherapeutic targets for biologic agents and systemic therapies in psoriasis treatment | ||
| Keywords | ||
| psoriasis | ||
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