Genetic Association between Interleukin IL-18-137G/C and IL-18-607 C/A polymorphisms and Type 1 Diabetes in Egyptian population | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 13, Issue 2, December 2014, Pages 47-54 | ||
| Authors | ||
| Ali Salim Al-Shehmany; Amira M. Embaby; Medhat A.Haroun; Ahmad A.El- Kafoury | ||
| Abstract | ||
| Abstract: Interleukin-18 also known as interferon-gamma inducing factor, Interleukin 18 is a cytokine that plays an important role in the T helper cell 1 response, by its ability to induce IFN- c production in T cells and natural killer cells. A functional variant of IL-18 gene has been reported as associated with type 1 diabetes (T1D). In the present study were analyzed two promoter single nucleotide polymorphisms (SNPs), at -607 (rs#1946518) and -137 (rs#187238) position, in 60 patient with type 1diabetes and 60 healthy individuals, both from Egyptian population. Allele and genotype frequencies of IL18 SNPs were compared in patients and controls .The genotype CC in -137 show significance according to the patient and their control (P<0.004) while the SNP – 607 don’t showed any significance between patient and control (P=0.641), respectively. Our finding suggested an association between IL18 promoter SNP -137 and susceptibility toT1DM in Egyptian population. | ||
| Keywords | ||
| interferon; gamma; Gene; polymorphism; Type | ||
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