Study of Signal Transduction Hypothetical Proteins of Helicobacter pylori | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 13, Issue 2, December 2014, Pages 1-17 | ||
| Authors | ||
| Zahra M. Al-Khafaji; Marium B. Mahmood | ||
| Abstract | ||
| Abstract: Hypothetical proteins of Helicobacter pylori strain 26695 were screened using MBGD database. There were about 714 (41.58 %) hypothetical proteins, 82.2 % were virulent proteins. Hypothetical proteins were categorized according to Gene Ontology grouping using ProtFunc server. Proteins in signal transduction group were selected for studying their characters. Post-translation modifications (PTMs) such as phosphorylation gave unclear results, Glycosylation such as N-linked Glycosylation was more frequent than O-linked Glycosylation among proteins. Secondary and tertiary structures were determined and pbd homologous (assigned with X-ray and NMR techniques) were assigned. Most proteins showed high interaction with cellular proteins and components. | ||
| Keywords | ||
| Helicobacter Pylori; Hypothetical proteins; Virulence; RaptorX; PTMs; STRING database | ||
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