H. Zain Al-Abdeen, S., J. Qasir, A. (2014). Synthesis of New β-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity. Alustath, 23(2), 42-50.
Salah H. Zain Al-Abdeen; Ahlam J. Qasir. "Synthesis of New β-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity". Alustath, 23, 2, 2014, 42-50.
H. Zain Al-Abdeen, S., J. Qasir, A. (2014). 'Synthesis of New β-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity', Alustath, 23(2), pp. 42-50.
H. Zain Al-Abdeen, S., J. Qasir, A. Synthesis of New β-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity. Alustath, 2014; 23(2): 42-50.

Synthesis of New β-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity

Iraqi Journal of Pharmaceutical Sciences
Article 1, Volume 23, Issue 2, December 2014, Pages 42-50
Authors
Salah H. Zain Al-Abdeen; Ahlam J. Qasir
Abstract
β-Adrenergic blocking agents, mostly comprising of β-amino alcohols, are of pharmaceutical significance and have received major attention due to their utility in the management of cardiovascular disorders including hypertension, angina pectoris, cardiac arrhythmias and other disorders related to the sympathetic nervous system. Most compounds available for clinical use belong to the aryloxypropanolamine series, which is considered the second generation of β-blocking agents. The present study includes the synthesis of compounds with an N-substituted oxypropanolamine moiety attached to the 1, 3, 4-thiadiazole derivatives. According to this information, eight compounds were synthesized and characterized by IR spectra and elemental microanalysis that confirmed the structural formula of these compounds.
Keywords
adrenoceptor blockers; thiadiazole; Schiff Base
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