Synthesis and Characterization of Novel 3-Chloro-Azetidine-2-One Derivatives From 2-Aminopyrimidine | ||
| Journals kufa for chamical | ||
| Article 1, Volume 0, Issue 6, February 2015, Pages 130-141 | ||
| Authors | ||
| Hawraa Mohammed; Ezat Hussein Zmam | ||
| Abstract | ||
| This work involved the synthesis of some derivatives of 3-chloro-azetidin-2-one, by two steps: The first include amino group of the 2-amino pyrimidine was condensed with different aromatic aldehydes and ketones in the presence of absolute ethanol to give new Schiff bases derivatives [A1 – A10] respectively . The second step , the resulting imines derivatives [A1 – A10] were reacted with chloro acetyl chloride in presence of triethylamine in 1,4-dioxan by pericyclic reaction to give novel 3-chloro-1-(pyrimidin-2-yl)azetidin-2-one derivatives [B1 – B10] respectively . All the prepared compounds were characterized by FT .IR spectroscopy , some of them were characterized by1H-NMR spectroscopy and C. H. N. S. analysis . | ||
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