Role of TGF-β1 in Urinary Bladder Carcinoma | ||
| Baghdad Science Journal | ||
| Article 1, Volume 11, Issue 4, December 2014, Pages 1481-1485 | ||
| Authors | ||
| Munther J. Hussain; Amna N. Jassem; Hind M. Mousa | ||
| Abstract | ||
| The present study aimed to evaluate sera TGF- β1 concentration in patients with urinary bladder carcinoma (UBC). All malignant of them was transitional cell carcinoma (TCC) type , patients with urinary bladder disorders (UBD ) and healthy control , and to study the correlation between sera TGF-β1 levels and tumor stages and grades in UBC patients . A direct ELISA test was used to quantify the seraTGF-β1 concentrations in sera of 58 patients with urinary bladder carcinoma UBC of different grades (G) and stages (T) all malignant of them was transitional cell carcinoma (TCC) type , 15 from patients with UBD and 15 healthy subjects . Sera levels of TGF-β1 were elevated in patients with UBC and UBD compared to healthy (P ≤ 0.01) .There was no association between tumor stages and serum level of TGF-β1 (P˃0.05) . Whereas there was an association between serum levels of TFG-β1 and tumor grades (p ≤0.05) . Increased serum level was found in high grades G≥2 of patient with UBC . | ||
| Keywords | ||
| Urinary bladder carcinoma; TGF | ||
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