Evaluation of antidiabetic and antihyperlipidimic activity of aqueous extract of Iraqi propolis in alloxan induced diabetes mellitus in Wister Albino rat | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 1, April 2014, Pages 88-94 PDF (0 K) | ||
| Author | ||
| Raeed Abdel mahdi Kassim Altaee | ||
| Abstract | ||
| The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of aqueous extract of Iraqi propolis (AEIP) in alloxan-induced diabetic rats. Diabetes was induced in Wister rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Animals were divided into five groups (n=6) in each receiving different treatments. Graded doses (150mg/kg and 300 mg/kg) of AEIP were studied in alloxan-induced diabetic rats for a period of 28th days. Glibenclamide (600 μg/kg) was used as a reference drug. For histomorphological study of pancreas , the animals were killed after 28 days , routine haematoxylin and eosin stain. In alloxan-induced diabetic rats, the daily oral treatment with AEIP significantly recover the weight (p>0.01) with respect to the control group, also a significant reduction in blood glucose. Besides, administration of AEIP for 28th days significantly(p>0.01) decreased serum contents of total cholesterol, triglycerides, low density lipoprotein LDL and very low density lipoprotein VLDL whereas HDL-cholesterol was effectively increased. The histopathological studies also indicated that AEIP is effective in regeneration of insulin secreting β-cells. Studies clearly demonstrated that AEIP possesses hypoglycemic and antihyperlipidemic effects mediated through the restoration of the functions of pancreatic tissues and insulinotropic effect. | ||
|
Statistics Article View: 178 PDF Download: 53 |
||