Cryo-induction of myocardial infarction in rats and its effects on Lactate dehydrogenase-1 level and histopathological changes | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 25, Issue 2, June 2014, Pages 49-58 | ||
| Author | ||
| Mahdi Haider Hammadi | ||
| Abstract | ||
| Our study used cryo-injury model to induce myocardial infarction in adult male rats by using liquid nitrogen (-190 co) and investigate the physiological changes during acute and chronic M.I through checking serum blood biomarker (Lactate dehydrogenase-1),and doing scoring between the biomarker and the histopathological changes in rats myocardium in different period time We used a total of 35 adult male rats and divided them in to subgroups as following: - Fifteen rats for induced acute myocardial infarction (4/hr., 8/hr. 24/hr.). - Fifteen rats for induced chronic myocardial infarction (7/days, 14/days, 28/days). - Five rats as a control healthy group. Lactate dehydrogenase-1 increased significantly at 4 hours post experimental induction of myocardial infarction and persist significantly high for 14 days then decline later on. The histopathological changes during acute and chronic M.I close related with the physiological changes in concentration of cardiac biomarker (LDH-1). On this results showed highly significant increase in concentration levels of serum LDH-1 at 4/hr. post experimental induction of M.I this results means the importance of LDH-1 as a specific and sensitive marker of myocardial necrosis ; and The histopathological changes during acute and chronic M.I it is close related with Approximation In Terms of a New Weighted Modulus Of Continuity With Applications Saheb and Ali 50 physiological changes occur in cardiac biomarker concentration and appear early in blood. | ||
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