SYNTHESIS AND CHARACTERIZAITION OF BISCYCLIC β- LACTAMS AS BLOOD CHOLESTROL INHIBITORS | ||
| JOURNAL OF THI-QAR SCIENCE | ||
| Article 1, Volume 4, Issue 3, December 2014, Pages 123-129 | ||
| Authors | ||
| Wisam Obaid Salman; Mahmood Shakir Magtoof | ||
| Abstract | ||
| This study is concerned with the synthesis and characterization of the 3-(4-chlorophenyl) bicyclic azetidin -2-one 3a. This compound 3a was prepared by reacting 3-(4-chlorophenyl) acetic acid with the appropriate Schiff’s base 2a in the presence of triethylamine with phosphorusoxychloride in dry dichloromethane under nitrogen atmosphere at -10˚C. The active acid chloride reacts with triethylamine to generate corresponding ketene in situ which further reacts with Schiff’s base to furnish corresponding 3-(4-chloroPhenyl)bicyclic azetidin 2–ones 3a.And it was a study of the activity biological to compound 3a to inhibition of cholesterol in the blood of some laboratory animals | ||
| Keywords | ||
| LACTAMS; CYCLOADDITION; CHLOROPHENYL | ||
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