Association of HLA DQA1 and HLA DRB1 Alleles with Asthma Patient In Basra City | ||
| Journal of Basrah Researches (Sciences) | ||
| Article 1, Volume 40, Issue 2, December 2014, Pages 129-137 PDF (0 K) | ||
| Authors | ||
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| Abstract | ||
| The current study were included one hundred and twenty blood sample with draw form patients with allergic asthma , they were selected randomly from the Allergy and Asthma Center in Basra city and there were eighty sample with draw from healthy individual as control . All samples from patients and controls were tested by direct ELISA for total IgE and Polymerase chain reaction was performed to detect a genetic relationship between allergic asthma and human leukocyte antigen classII allele (HLA- DQA1 and HLA- DRB1 alleles).Result of this study showed that the total IgE>100 IU/ml had higher rate in asthma patients at (70.8%).with significant difference( p<0.05) between total IgE<100 IU/ml and controls. The study also included detection of some human leukocyte antigens (HLAclassII) alleles HLA DRB1*0101/2/4 , HLA DQA1*0401, HLA DQA1*0101/4 by the use of PCR analysis to determine their impact on the asthma allergy. The results of this analysis revealed the HLA DQA1*0401 had higher rate at(89.2%) in asthma patients ,also this allele appeared in 100% of asthma patients who had total IgE>100 IU/ml . All studied HLA class II alleles were significantly (P<0.05) distributed in the study groups . | ||
| Keywords | ||
| Asthma; HLA antigens; IgE; Genetic | ||
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