cytogenetic effect of caramel coloring in the blood cells of the human lymph | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 7, Issue 1, June 2014, Pages 92-98 | ||
| Authors | ||
| Nahi Yousif Yaseen; Mohemmed Omar; Aklas M. Farhan | ||
| Abstract | ||
| caramel food colorings which are used widely in products and processed foods , as used in the manufacture of sweets and soft drinks , and in recent years has raised a lot of doubts and warnings about its use . The fact that these pigments have direct contact to human health , especially children , and due to the lack of studies illustrate precisely the toxic effects and genetic these colorings , this study was to shed light on the effect of cytogenetic for dyes caramel ( Category IV ) , in different concentrations ( 5,10,15,20 ) µg / mL , blood cells in human lymphocytes (in vitro) Using cytogenetics Parameters (Mitotic Index(MI) ,chromosomal aberrations(CA) , and Micronucles (MN). These results indicate that the colorings caused chromosomal changes consisted of The Chromosome Aberration represented by chromosomal and chromatid breaks, chromosomal and chromatid gap, and dicentric chromosome, also caused a reduction in( Mitotic Index(MI) and increase of micronuclei . | ||
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