Immunohistochemical assessment of Cox-2, and ki-67 expression in gastric cancer | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 7, Issue 1, June 2014, Pages 16-20 | ||
| Authors | ||
| Wasan A. Bakir; Nahi Y.Yaseen; Zahraa A. Mohammed; Ayser H. Latef; Hayder A. Hasoon | ||
| Abstract | ||
| Cell proliferation characteristics may reflect the aggressiveness of gastric cancer and their eventual prognosis. The aim of this study was to evaluate whether the proliferative activities determined by Ki-67 labeling index (LI) could be used as a predictor in patients with gastric cancer, and examine the relation between COX-2 and Ki-67 expression and gastric cancer. The expression of COX-2 and Ki-67 were detected in 40 patients with gastric cancer and 30 healthy individuals were assessed by immunohistochemistry. The biopsies were fixed in 10% buffered formaldehyde solution, embedded in paraffin and stained immunohistochemically with anti-human COX-2 and Ki-67 antibodies. Expression of Ki-67 andCOX-2was significantly higher in tumor compared with control samples.A significant correlation was found between COX-2 and Ki-67 protein expression. In conclusion,the expression of COX-2 and Ki-67 proteins was closely connected with gastric cancer. | ||
| Keywords | ||
| COX; gastric cancer | ||
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