The Effect of alcoholic extract of Nigella sativa in fertility of mature white male mice treated with cadimium acetate | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 0, January 2014, Pages 212-221 PDF (0 K) | ||
| Abstract | ||
| The present study aimded to investigate the effect of alcoholic extract of Nigella sativa in minimizing the deleterious effect of cadimium in fertility of mature male mice with the histopathological changes of testes.Results illustrated histopathological changes in the testes of mice which were intraperitonealy injected by 3 and 5 mg/kg B.W.of cadimium acetate, the effect was increased by increased concentration,mean while ,that were treated by cadimium with alcoholic extract of Nigella sativa for both concentration did not show any histopathological changes as compared with the control treatment , and the group which was treated by cadimium led to a significant reduction (p<0.05) in testes weights as compared with the control . In addition, it was noticed that the group treated by cadimium and water extracted Nigella sativa did not show any differences in body and testes weighs for both concentration in comparasion with the control ..Groups which were treated by both concentrations of cadimium caused significant reduction (p<0.05) of sertoli cells in comparasion with that of the control, mean while ,it was noticed that groups treated with cadimium caused significant reduction (p<0.05) in numbers of spermatogonia,spermatocytes and spermatids for both concentrations in comparasion with the control . Groups treated with cadimium and alcoholic extract of Nigella sativa did not show any significant differences(p>0.05) in numbers of sperms for both concentrations as compared with the control. The study indicated that treatment with cadimium caused cessation of spermatogenesis in semineferous tubules due its cytotoxic effect and it causes changes in metabolic processes in cells mean while Nigella sativa had an effect against deleterious and toxic effect which was induced by cadimium which had acurative effect against free radicals formed by cadimium . | ||
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