Synthesis and Identification of some 1,3-oxazepine derivatives containing p-methoxy phenyl and studying their anti bacterial activity | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 5, Issue 7, June 2014, Pages 31-41 PDF (0 K) | ||
| Author | ||
| Bushra A.Kherallah | ||
| Abstract | ||
| This search includes preparation p-methoxy benzoyl hydrazine (II2) from the reaction between p-methoxy ethyl benzoate (I1) with hydrazine haydrate with the existence of ethanol absolute , then they were converted to hydrazine derivatives with different substituents (III3-6) through the reaction with aromatic benzaldehyde with out using a solvent under thermal fussion . Compounds of 1,3-oxazepine-4,7-dione (IV7-10) have also been prepared by ring closer reaction through the treatment of the prepared hydrazones (III3-6) and maleic anhydride ,The structure of the synthesis compounds was confirmed by FT-IR and 1HNMR spectral data , as the physical means ,the biological activity was studied againt two types of bacteria. | ||
| Keywords | ||
| seven heterocyclic rings; oxazepine; methoxy phenyl | ||
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