Correlation of New Vitamin C Derivatives with Alanine Amino Transferase and Aspartate Amino Transferase Activities | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 11, Issue 2, June 2014, Pages 285-291 | ||
| Authors | ||
| Mufeed J.Ewadh; Seenaa Badr; Ibtesam H. Al Musawi; Hamid G. Hasan; Hiba Resheed Behayaa | ||
| Abstract | ||
| Background: Liver enzymes are commonly found in liver cells and when the liver is damaged, liver cells release their enzymes into the blood stream. Vitamin C is a low-weight molecular antioxidant and is effective in the aqueous phase in protecting different parts of cells against free radicals. An enzyme inhibitor is a molecule, which binds to enzymes and affect their activity. Objective: This study was carried out to investigate the effect of new vitamin C derivative on serum liver enzymes. Research design and methods: Eight samples were used. Liver enzymes activity measured with and without vitamin C derivative. Results: The result showed a reduced activity of aspartate aminotransferase (AST), and alanine transferase (ALT) after addition of vitamin C derivative. Conclusion: It is concluded that the decrease in ALT, and AST activities were due to noncompetitive inhibition of enzymes by vitamin C derivative. | ||
| Keywords | ||
| Alanine aminotransferase; aspartate aminotransferase; vitamin C derivative; enzyme inhibition | ||
|
Statistics Article View: 36 PDF Download: 5 |
||