The Impact of Methotrexate on Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Level in Rheumatoid Arthritis Patients | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 25, Issue 1, March 2014, Pages 1-6 | ||
| Author | ||
| Maha Mohsin | ||
| Abstract | ||
| Granulocyte macrophage colony stimulating factor has been inducted as a mediator of inflammationin rheumatoid arthritis (RA). Methotrexate is the most commonly used disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis.This study was undertaken to evaluate the role of granulocyte macrophage colony stimulating factor in rheumatoid arthritis and to investigate the influence of methotrexate on serum level of this cytokine. The current study covered 70 subjects. It comprised a total of 40 patients with rheumatoid arthritis (20 patients without treatment and 20 patients were on methotrexate therapy) compared with 30 apparently healthy control. Enzyme-linked immunosorbent assay was used to detect serum level of granulocyte macrophage colony stimulating factor. Serum levels of granulocyte macrophage colony stimulating factor was significantly higher in RA patients than in healthy controls (P<0.01).Furthermore, median serum level of granulocyte macrophage colony stimulating factor was significantlydecrease in patients treated with methotraxate as compared to those patients who have received no treatment (P<0. 05). In conclusion, the results suggested that granulocyte macrophage colony stimulating factor may play a role in pathogenesis of rheumatoid arthritis, and methotrexate has an observed effect on this cytokine in sera of patients. | ||
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