GHRELIN AND INSULIN RESISTANCE IN A SAMPLE OF IRAQI WOMEN WITH POLYCYSTIC OVARY SYNDROME | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 12, Issue 1, April 2014, Pages 51-59 | ||
| Authors | ||
| Amal A. Hussein; Rayah S. Baban; Alaa G. Hussein | ||
| Abstract | ||
| Background:Polycystic ovary syndrome is associated with adiposity and metabolic changes predisposing to insulin resistance and diabetes mellitus. Ghrelin is an appetite-stimulating hormone, which acts through its receptor on the hypothalamus to regulate energy balance and thus plays a major role in the etiology of metabolic diseases. Objective:To investigate the relation between ghrelin hormone and insulin resistance in patients with polycystic ovary syndrome. Methods:Thirty nine women with polycystic ovary syndrome and 30 healthy controls were examined. Fasting ghrelin, insulin, glucose, lipid profile concentrations were determined. Insulin resistance indexes were calculated (HOMA-IR and QUICKI-IR indexes). Results:Serum ghrelin concentration was significantly lower in polycystic ovary syndrome patients than control subjects (235 ± 17.36 pg/ml Vs 489.7 ± 53.4 pg/ml). Insulin resistance and BMI were significantly higher in polycystic ovary syndrome than control group. Conclusion:Ghrelin hormone may be used as a new additional marker in the diagnosis of polycystic ovary syndrome. Hyperinsulinaemia and hyperleptinemia are associated features in polycystic ovary syndrome. Keywords:Ghrelin, Obesity, Polycystic ovarian syndrome (PCOS), Body mass index (BMI), Insulin resistance | ||
| Keywords | ||
| Ghrelin; Obesity; Polycystic ovarian syndrome; Body mass index; Insulin resistance | ||
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