Comparison Between the Effect of Antimlarial Drug Produced by Local | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 9, Issue 1, June 2014, Pages 1-10 PDF (0 K) | ||
| DOI: 10.32894/kujss.2014.89140 | ||
| Authors | ||
| Mohammed Abdul-Aziz Kadir; Nuria Abdul-Hussein; Ayhan Rashid Mahmoud | ||
| Abstract | ||
| Local isolate of Streptomyces sp.1 showed ability to produce antimalarial activity against P.vivax, it caused a great reduction in the number of the parasite. The inhibition percentages during 24 and 48 hours were 60.90, 88.38 respectively. Purification of antimalarial agent produced by Streptomyces sp.1 was done by extraction with ethylacetate followed by methanol, and application of gel filtration (Sephadex LH-20, Silica gel column) which resulted in brownish compound. This compound named as SAN 1. Drug, antibiotics and SAN1 inhibited the growth of P. vivax in vitro. The highest inhibition value (87.55%) was observed when 1000 g/ml of trimethoprim was added to cultural medium, followed by chloroquine, primaquine, chloramphenicol, tetracycline, streptomycin, SAN1, rifamycin, erythromycin, ampicillin with inhibition percent 86.09, 83.81, 81.74, 78.83, 78.66, 78.42, 75.10, 74.27 and 74.06% respectively | ||
| Keywords | ||
| chemical drugs; Streptomyces; vivax | ||
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