Assessment of Adenosine deaminase specific activity in serum and saliva of patients with chronic gingivitis | ||
| Jornal of Biotechnology Research Center | ||
| Article 1, Volume 8, Issue 2, June 2014, Pages 37-40 | ||
| Authors | ||
| Hazema Mossa Khalil; Zahraa Hussein M. Kadri; Hadeel Khlil Rahman | ||
| Abstract | ||
| Adenosine deaminase (ADA) is an enzyme that catalyzes the deamination of adenosine to inosine. The enzyme is widely distributed in human tissues and work as a marker of cellular immunity, and its activity is found to be elevated in those diseases in which there is a cell-mediated immune response. The aim of this study was to explore the usefulness of ADA specific activity in serum and saliva as a biomarker of chronic gingivitis (CG). Thirty CG patients and 15 CG-free controls were enrolled in the study, and they were attendant of the Dental Clinic at the College of Dentistry Medicine (University of Baghdad) during the period January-March 2013. The results demonstrated that the ADA mean specific activity was significantly (P ≤ 0.001) increased in serum (17.58 ± 0.81 vs. 0.75 ± 0.03 U/mg protein) and saliva (85.43 ± 2.43 vs. 0.11 ± 0.03 U/mg protein) of CG patients as compared with controls. Accordingly, it is possible to conclude that ADA specific activity might be a good biomarker for CG, especially in saliva, and can reflect inflammatory and destruction processes in the periodontal tissue. | ||
| Keywords | ||
| chronic gingivitis; Adenosine deaminase enzyme | ||
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