Development of Spectrophotometric Method for the Determination of Metoclopramide. HCl in a Pharmaceutical Preparations | ||
| Rafidain Journal of Science | ||
| Article 2, Volume 25, Issue 3, June 2014, Pages 10-21 PDF (0 K) | ||
| DOI: 10.33899/rjs.2014.88564 | ||
| Authors | ||
| Rowa N. Aljarah; Aseel N. Obedagha | ||
| Abstract | ||
| This paper includes a development of spectrophotometric method for the determination of metoclopramide.HCl. The method involves the diazotization of metoclopramide.HCl and coupling with pyridoxine. HCl, to form an intense orange colored, water-soluble and stable azo-dye which shows a maximum absorption at 470 nm. Beer's law is obeyed over the range 0.5-30 µg/ml metaclopramide. HCl with a molar absorptivity of 1.98*104 L.mol-1.cm-1, The average recovery is 99.27% and relative standard deviation of 0.124 to 0.778%. This method has been applied successfully to the determination of metoclopramide.HCl in pharmaceutical preparations. | ||
| Keywords | ||
| Spectrophotometric method; metoclopramide; Hcl; diazotization coupling method | ||
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