ACUTE TOXICITY STUDY OF NEW DAPSONE SCHIFF BASE DERIVATIVE IN LABORATORY RATS | ||
| Basrah Journal of Veterinary Research | ||
| Article 1, Volume 13, Issue 1, June 2014, Pages 150-156 PDF (0 K) | ||
| DOI: 10.33762/bvetr.2014.88135 | ||
| Authors | ||
| Wasfi A. Al-masoudi; Hassan T. hamed; Jalaa Al- ahamed | ||
| Abstract | ||
| Dapsone (4,4-diaminodiphenylsulphon) is one of the types of sulfa drugs as an anti bacterial and is used particularly in the treatment of leprosy . The aim of present study to investigate in vivo toxic effect and find acute toxic doses ( LD50) of new dapsone Schiff base derivative compound ( 4-{[ 4(ethylideneamino)phenyl] sulfonyl} aniline, was evaluated in this study. The experiment was performed on 10-14-week old male and female albino rats ( 225± 25 g ) at the time of treatment. Its acute toxic dose being 0.58 g. | ||
| Keywords | ||
| Dapsone; Albino rats; leprosy | ||
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