Synthesis and Characterization of Novel Oxazolidinones Via Schiff Base Reactions | ||
| Journal of University of Anbar for Pure Science | ||
| Article 19, Volume 7, Issue 1, April 2013, Pages 74-80 PDF (642.22 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2013.83186 | ||
| Authors | ||
| Obaid H.Abid; Aws K. Mohamed | ||
| University of Anbar - College of Education for Pure Science. | ||
| Abstract | ||
| A number of new novel 2,3-disubstituted-1,3-oxazolidine-5-one derivatives were synthesized by the reaction of Schiff‘s bases with chloroacetic acid in dry banzene with high yields. Schiff bases were synthesized by the reaction of heteroaromatic aldehydes or ketones with primary heterocyclic amines. The products were identified by their melting points and spectral features ( FT-IR and UV-Vis-spectra and 1HNMR spectra ). | ||
| Keywords | ||
| oxazolidinones; Schiff base; Chloroacetic acid | ||
| References | ||
|
1- Barbachyn, M. R.; Ford. C. W, Angew. Chem. Int. Ed., 2003,42, 2010-2023.
2- Ager, D. J.; Prakash, I.; Schaad, D. R., Chem. Rev.,1996,835-875.
3- Clemett, D.; Markam, Drugs, 2000,59,815.
4- Barbachyn, M. R. Hutchinson, D. K.; Bricker, S. J.; Zurenko, G. E., J. Med. Chem.,1996,39,680-685.
5- Renslo, A. R.; Jaishankar, P.; Venkatachalam, R.; Hackbarth, C.; Lopez, S.; Patel, D. V; Gordeev, M. F, J. Med. Chem.,2005,48, 5009-5024.
6- Makhtar, T. A.; Wright, G. D. , Chem. Rev.,2005,105,529-542.
7- Aurelio, L.; Brownlee, R. T. C.; Hughes, A. B., Chem. Rev.,2004, 104,5823-5846.
8- Waizumi, N.; Fukuyama, T. I. T., J. Am. Chem. Soc.,2000,122, 7825-7826.
9- Slee, M. A.; Wuonola, M. A.; Meripley, R. J.; et al, Antimicrob. Agents Chemother.,1987,31,1791-1797.
10- Gregory, w. A.; Brittelli, D. R.; Wang, C. L.; Bartholomew, P. T.; Slee, A. M.; Forbes, M., J. Med. Chem.,1989,32,1673.
11- Wang, C. L.; Gregorg, W. A.; Wuolona, M. A., Tetrahedron,1989, 45,1323.
12- Kim, C.; Ko, S. Y., Bull. Korean Chem. Soc.,201132,,4450.
13- Brickner, S. J.; Hutchinson, D. K.; Barbachyn, M. R.; Manninen, P. R.; Ulanawicz, D. A.; Germon, S. A,; Grega, K. C.; Hendges, S. K.; Toops, D. S.; Ford, C. W,; Zurenko, G. E., J. Med. Chem.,1966, 39,673.
14- Shinabarger, D. I.; Marotti, K. R.; Murrat, R. W.; Lin, A. H.; Melchior, E. P. Swaney, S. M.; Dunyak, D. S.; Demyan, W. F.; Buysse, J. M., Antimicrob. Agents Chemother.,1997,41,2132.
15- Marches, A.; Schito, G. C., Eur. Soc. Clinc. Micr. Infect. Deseases, CMI,2001,7,66-74.
16- Park, C. S.; Kim, M. S.; Sim, T. Bo.; Pyun, Do. K.; Lee, C. H., J. Org. Chem. Article,2002,XXXX.XX,A-G.
17- Philips, O. A.; Udo, E. E.; Ali, A. A. M.; AL-Hassawi, N., Biorg. Med. Chem., 2002,11,35-41.
18- Manninen, P. R.; Brickner, S. J., Org. Syn,2005,81, 112-116.
19- Cui, Y.; Dang, Y.; Yang,Y.; Ji, R., Current Science,2005,89(3), 531-535.
20- Hwang, J. M.; Yeom, S. H.; Jung, K. Y., J. Ind. Eng. Chem.,2007, 13(3),474-479.
21- Cruz, A.; Rivero, I. A., J. Mex. Chem. Soc,2009,53(3),120-125.
22- Park, H. G.; Kim, B.; Bae, B.; Lim, B.; Ko, M.; Oh, S.; Kim, H., Bull. Korean Chem. Soc.,2012,33(4),1389-1392.
23- Venkanna, G.; Madhusudhan, G.; Mukkanti, K.; Samrath Kumar, Venu, K., Der Pharma Chemica,2012,4(1),428-436.
24- Renslo, A. R.; Jaishankar, P.; Venkatachalam, R.; Hackbarth, C.; Lopez, S.; Patel, D. V. and Gordeev, M. F., J. Med. Chem., 2005,48, 5009-5024. | ||
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