Evaluation of cellular immune response provoked by experimental infection with Cryptosporidium spp. in mice | ||
| Jornal of Biotechnology Research Center | ||
| Article 1, Volume 8, Issue 1, March 2014, Pages 8-13 | ||
| Authors | ||
| Harith S.J. AL-Warid; Souhaila H. Mahmood; Ihsan M. Alsaqur | ||
| Abstract | ||
| Experimental infection was induced in immunosupreesed and non-immunosupressed mice using inoculation of two different Cryptosporidium spp. isolates: faecal origin and river water origin; then the infectivity rate and cellular immunological status were examined in these groups of mice. The results indicated that these two isolates induced experimental infection in immunosuppressed and non-immunosuppressed mice with no significant differences in infectivity rate between groups. Immunosuppressed mice infected with feacal or water origin oocyst showed low and significant values of transformed lymphocytes 8.68% ± 0.65%, 9.18% ± 1.09 respectively and phagocytic index 10.1% ± 1.66 and 11.2% ± 0.19 respectively. It concludes that lymphocyte transformation and phagocytosis index are good indicators to evaluate the cellular immune response in infected experimental mice with Cryptosporidium. | ||
| Keywords | ||
| Cellular Immune; Cryptosporidium | ||
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