Oxidative Stress in Post-traumatic Stress Disorders for Terror Attack Victims in Iraq† | ||
| Journal of University of Babylon | ||
| Article 1, Volume 22, Issue 1, January 2014, Pages 408-416 | ||
| Authors | ||
| Abdulsamie H. Alta; Tarik Hufdy Al-Khayat; Waleed Azeez Al-Ameedy; Lamia Abdul Majeed | ||
| Abstract | ||
| Background: There is accumulating evidence for a link between posttraumatic stress disorder (PTSD) and reduced health status for terror attack victims. Objective: To assess the oxidants/ antioxidant status in patients with PTSD. Patients and Methods: 70 Iraqi subjects (59 males, 11 females) witnessed on Alnasej Factory explosion occurred at 10th June 2010 in Hilla city of Iraq, as well as 35 apparently healthy persons served as a controls group (21 males, 14 females) were subjected to present study. Participants were grouped to four groups according to PTSD Checklist (PCL) scores. Antioxidant enzymes superoxide dismutase (SOD) catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and lipid peroxidation were determined using spectrophotometric methods Results: The antioxidant enzymes activities, SOD, GPx, and peroxidation product MDA, found to be insignificantly increased in the present study, whereas, the antioxidant enzyme activity CAT and non-enzymatic antioxidant GSH showed an insignificant decreased in all groups of PTSD patients, when compared to control group. Also there are positive correlations between SOD, GPx and MDA, with severity of PTSD. Whereas; there is negative correlation between CAT and GSH with severity of PTSD. Conclusion: Results may indicate an involvement of mild oxidative stress in the pathogenesis of PTSD due to active hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-thyroid (HPT) axis. † This paper is a part of a doctoral thesis and the work is still underway to complete the study. | ||
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