Assessment of Chemokine (Interleukin -8) and Interferon–γ (IFN- γ) among Autoimmune Hepatitis patients in association with certain viral infections. | ||
| Journal of University of Babylon | ||
| Article 1, Volume 22, Issue 1, January 2014, Pages 303-309 | ||
| Authors | ||
| Raheem Tuama O. AL; ; Azhar Emran AL-Thahab; Alaa Sadeq Al-Awad | ||
| Abstract | ||
| Thirty five (35) patients clinically diagnosed as autoimmune hepatitis (AIH) attending Gastrointestinal (GIT) center in Merjan medical city and (30 matched age person ) as a control group enrolled in this study in the period between January and August 2012 . Specific anutoantibodies done to confirm diagnosis and classify of AIH types such as (ANA, ASMA, LKM, LSP) IL-8, IFN- γ, and hepatitis screen for HCV infection also done . The result show that female is more susceptible to infected with AIH rather than male, and young age group is more susceptible for infection than other age group. Highly significant increased ( P<0.01 ) of cytokines (IL-8) in compareson with control as well as highly significant of IFN- γ. The major group of patients at type 1 AIH and other types are less. Patients may present without circulating autoantibodies, referred to as (autoantibody-negative autoimmune hepatitis) or type 4 AIH gave significant group of AIH. Cytokines level important to monitored the severity of damage and whether the patients with good or bad prognosis, so that recommended to study other different types of cytokines for Th1, Th2, and NK cell activators to predict of ability to producing pro-inflammatory and anti-inflammatory mediators as well as ability to treatment of such diseases. | ||
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