Correlation between Antiapoptotic Gene Product Protein Expression in Oral Carcinoma with Age and Gender of Patients | ||
| Journal of University of Babylon | ||
| Article 1, Volume 20, Issue 4, October 2012, Pages 1291-1302 | ||
| Authors | ||
| Ikapal Al Kaptan; Raja Kummoona; Header Dakhel AL- Muala; Suha mohammad sami | ||
| Abstract | ||
| Oral cavity cancer represent a multiplicity of disease, Squamous cell carcinoma represents the most common frequent malignant tumor of the oral cavity. Aims :- To identify Bcl-2 oncogene product expression of oral carcinoma and its correlation to the age and sex of patients. Patients and methods :- Twenty four patients were presented with oral carcinoma , Formalin-fixed paraffin-embedded sections were stained with H and E and immunohistostaning . Primary antibody kit (Bcl-2 onco-protein ready to use) clone 124 Dako corporation . Results:-Bcl-2 immunohistochemical expression is confined to the basal cell layers in normal oral mucosa , while Bcl-2 expression in oral carcinoma is peripherally located with in infiltrating tumor cells , which were more intensely stained . they may be genetically damaged or mutated cells not eliminated by apoptosis , this lead to alter the ratio of Bcl-2 / Bax and hance lead to over expression of Bcl-2 . There was no correlation between Bcl-2 expression and the age and sex . Conclusion :- Bcl-2 expression in normal oral mucosa and oral carcinoma, Bcl-2 immunoreactivity did not correlated neither to the age nor gender of the patients | ||
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