Effect of penicillin on uterus in mice | ||
| Iraqi Journal of Embryos and Infertility Researches | ||
| Article 1, Volume 2, Issue 4, December 2012, Pages 52-57 | ||
| Abstract | ||
| Background: Background: The reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility, there is sufficient evidence to hypothesize that antibiotic may influence the fertility. Objeclive: This study was established to explore the individual impact of different doses of penicillin on some reproductive parameters. Materials and Methods: Forty adult female albino mice (12-18 weeks) and weight (25- 28) gm divided into four groups. Control group (G1) was treated daily with normal saline, and other three groups that treated with different doses of penicillin G2 (2mg/kg/B.wt), G3 (3mg/kg/B.wt), G4 (4mg/kg/B.wt)for four cycles twice daily (IM) injection at proestrus phase and sacrificed at estrus phase. Parameters were assessed include, thickness of endometrium, length of epithelial cells, number and diameter of uterine gland using histological section and measurement by (motic image plus). Results: The results of this study demonstrate that there is significant decrease (P<0.05) in thickness of endometrium, height of epithelial cell, number and diameter of uterine glands of female mature mice after treatment with high doses (3mg/kg/B.wt), while, there is no significant decrease (P>0.05) after treatment with (2mg/kg/B.wt); (3mg/kg/B.wt) compare to control group. Conclusion: The result showed higher doses for long period of penicillin has impact of some reproductive parameters of mature female mice. | ||
| Keywords | ||
| penicillin; Reproduction; mice | ||
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