Evaluation of some trace elements in type 2 diabetes mellitus patients | ||
| AL-yarmouk Journall | ||
| Article 1, Volume 0, Issue 1, June 2015, Pages 5-21 | ||
| Authors | ||
| Numan Abduallateef; Suhayla Khalied | ||
| Abstract | ||
| Noninsulin dependent diabetes mellitus is supposed to be associated with fluctuations in the plasma levels of several trace elements. There is accumulating evidence that the metabolism of several trace elements is altered in patients with noninsulin dependent diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progression of this disorder. Aim The aim of the present study is to compare the levels of essential trace elements including copper (Cu), zinc (Zn), magnesium (Mg), iron (Fe), and calcium (ca) in type 2 diabetic patients , healthy controls . and their possible association with age, sex and glycemic status. Materials and methods The comparative study included 100 type 2 diabetic patients and 30 as healthy control. Blood samples of all the subjects were collected after an overnight fasting for the determination of blood glucose, magnesium, zinc, copper, iron and calcium. Fasting blood sugar (FBS) was determined by enzymatic colorimetric assay to confirm the status of the patients and the controls while metals’ concentrations were measured with Atomic Absorption Spectrophotometer. Results The mean values of serum Mg and Zn levels were significantly reduced in blood samples of diabetic patients as compared to control subjects (p<0.01).The serum Cu , Fe and Ca were significantly higher in blood samples of diabetic patients compared to normal subject (p<0.01). Sex and age did not affect the trace elements concentration except Cu showed a statistically significant increase with age. Glycemic status effect the trace elements concentrations significantly. Conclusion The results confirm that alteration of some essential trace metals are associated with diabetes mellitus. | ||
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