Synthesis, Characterization and Biological Activity Study of Some New Schiff Bases Derived From Phenyl quinoline-2(1H)-one | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 5, Issue 2, December 2012, Pages 114-122 | ||
| Author | ||
| R. S. Dawood | ||
| Abstract | ||
| This research comprises the preparation of new phenyl quinoline derivatives. The cinnamic acid was reacted with aniline derivatives in absolute ethanol to produce the substituted of4-phenylquinolin-2(1H)-one (1a-c). Treatment of (1a-c) with hydrazine hydrate to give hydrazone (2a-c), then the hydrazone (2a-c) was used to react with formic acid and different aromatic aldehydes to obtain the1,2,4-triazole derivatives (3a-c) and azomethines (4,5a-c) respectively via Schiff bases formation. The compounds obtained were characterized by such spectroscopy means namely FT-IR, U.V and1H-NMRanalysis. Biological activity for some of the prepared compound were evaluated against two types of bacteria (Escherichia Coli and Staphylococcus aureus). The results in general showed that all the tested compounds possess good biological activity against the tested organisms. | ||
| Keywords | ||
| Quinoline; Triazole; azomethine | ||
|
Statistics Article View: 108 PDF Download: 66 |
||