The Role of Oxidative Stress in Vitiligo and Alopecia Areata | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 23, Issue 4, December 2010, Pages 287-291 | ||
| Authors | ||
| Estabraq A. Al-Wasiti; Sami Mohammed Al-Tammimy; Wasan Taha Al-Rubayee | ||
| Abstract | ||
| Abstract Background: The pathogenetic mechanism in vitiligo and alopecia has not been completely clarified. One of the major hypotheses in the pathogenesis of these diseases is oxidative stress hypothesis. Oxidative stress may be induced by increasing the generation of reactive oxygen species (ROS) and other free radicals. Objectives: The objective of the present study is to evaluate the role of oxidative stress in pathogenesis of vitiligo, and Alopecia areata. Materials & Methods: Twenty patients with generalized and localized vitiligo, 20 patients with alopecia areata, and 25 controls were included in this study. We examined serum levels of malondialdehyde (MDA), super oxide dismutase (SOD) and vitamins E and A in patients with vitiligo and alopecia areata and control subjects. Result: The level of MDA in serum with patients with vitiligo and alopecia (2.07±0.43, 1.73±0.31, respectively) were significantly higher than those of control (0.85±0.12; p<0.0001). The SOD activity (8.94±0.38, and 8.809±0.44, correspondingly) in serum of patients with vitiligo and AA were significantly lower than that of controls (10.142±2.61). The level of vitamin A in serum of patients with vitiligo and AA (53.47±2.27, 52.85±2.34, respectively) were significantly lower than control (59.48±0.92, p<0.0001), while vitamin E levels in serum did not differ statistically. Conclusion: increased lipid peroxidation may relate to decrease in SOD activity and vitamin A levels. These results demonstrate the presence of an imbalance in the oxidant-antioxidant system and provide further support for a free radical-mediated damage as an initial pathogenic event vitiligo and AA. Key Words: Oxidative Stress, Vitiligo, Alopecia Areata | ||
| Keywords | ||
| oxidative stress; Vitiligo; alopecia areata | ||
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