Determination of guanase activity in patients with prolonged treatment with simvastatin | ||
| Al-Qadisiah Medical Journal | ||
| Article 1, Volume 8, Issue 2, December 2012, Pages 44-49 PDF (0 K) | ||
| Author | ||
| Sawsan Hassan kathem | ||
| Abstract | ||
| In this study, 28 patients suffering from hyperlipidemia who were on simvastatin ,were included for determination serum guanase activity. Guanase activity was observed at high level in those patients (n = 16) who were on prolonged treatment with simvastatin (more than 30 days) but its activity remained within normal when simvastation was administrated at interrupted intervals . The results were compared with two control groups the first (n=10) with hyperlipidemia but with no simvastatin and the second (n=10) was normal individuals with no history of hyperlipidemia. However, guanase activity was found to be normal in both control groups . Besides, this study was found that alkaline phosphatase was also increased in some patients , However , guanase activity was observed earlier than alkaline phosphatase which have suggested that simvastatine could cause liver injuries when used for a long time. This study is the first study conducted to predict liver injuries as a result of simvastatin through guanase elevation . | ||
| Keywords | ||
| guanase; Simvastatine | ||
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